Anti-stiffness effect of apocynin in deoxycorticosterone acetate-salt hypertensive rats via inhibition of oxidative stress

This study sought to determine if apocynin, a nicotinamide adenine dinucleotide phosphate oxidase inhibitor, would attenuate arterial stiffness in salt-sensitive hypertensive rats via structural and functional changes in conduit arteries. We showed that tail blood pressure was significantly higher i...

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Veröffentlicht in:	Hypertension research 2013-04, Vol.36 (4), p.306-312
Hauptverfasser:	Chen, Qi-Zhi, Han, Wei-Qing, Chen, Jing, Zhu, Ding-Liang, Chen-Yan, Gao, Ping-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - pharmacology Animals Antioxidants - pharmacology Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Blood Pressure - drug effects Carotid Arteries - chemistry Carotid Arteries - metabolism Collagen - metabolism Desoxycorticosterone Elastin - metabolism Hypertension - chemically induced Hypertension - drug therapy Hypertension - pathology NADPH Oxidases - biosynthesis Oxidative Stress - drug effects Pulse Wave Analysis Rats Reactive Oxygen Species - metabolism Sodium Chloride Vascular Stiffness - drug effects
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Zusammenfassung:	This study sought to determine if apocynin, a nicotinamide adenine dinucleotide phosphate oxidase inhibitor, would attenuate arterial stiffness in salt-sensitive hypertensive rats via structural and functional changes in conduit arteries. We showed that tail blood pressure was significantly higher in deoxycorticosterone acetate-salt-induced hypertensive (DSH) rats compared with the sham control group (P
ISSN:	0916-9636 1348-4214
DOI:	10.1038/hr.2012.170