Synthesis of 3‑Cyanoindole Derivatives Mediated by Copper(I) Iodide Using Benzyl Cyanide

Copper-mediated direct and regioselective C3-cyanation of indoles using benzyl cyanide as the cyanide anion source is presented. A wide range of indoles undergo cyanation smoothly by employing a reaction system of copper(I) iodide under open-to-air vessels.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2013-04, Vol.78 (7), p.3374-3378
Hauptverfasser:	Yuen, On Ying, Choy, Pui Ying, Chow, Wing Kin, Wong, Wing Tak, Kwong, Fuk Yee
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitriles - chemistry Copper - chemistry Indoles - chemical synthesis Indoles - chemistry Iodides - chemistry Molecular Structure Nitriles - chemical synthesis Nitriles - chemistry
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Beschreibung
Zusammenfassung:	Copper-mediated direct and regioselective C3-cyanation of indoles using benzyl cyanide as the cyanide anion source is presented. A wide range of indoles undergo cyanation smoothly by employing a reaction system of copper(I) iodide under open-to-air vessels.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo3028278