Metal-free, highly efficient organocatalytic amination of benzylic C-H bonds

Metal-free, highly efficient organocatalytic amination of benzylic C-H bonds

A new synthetic approach toward direct C-N bond formation through sp(3) C-H activation has been developed under metal-free conditions. Both primary and secondary benzylic C-H substrates could react smoothly with various amines to give only mono-amination products with good to excellent yields.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (35), p.3700-3702
Hauptverfasser: Xue, Qicai, Xie, Jin, Li, Huamin, Cheng, Yixiang, Zhu, Chengjian
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Amines - chemistry
Benzene Derivatives - chemistry
Carbon - chemistry
Catalysis
Hydrogen - chemistry
Nitrogen - chemistry
Oxidants - chemistry
tert-Butylhydroperoxide - chemistry
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Zusammenfassung:A new synthetic approach toward direct C-N bond formation through sp(3) C-H activation has been developed under metal-free conditions. Both primary and secondary benzylic C-H substrates could react smoothly with various amines to give only mono-amination products with good to excellent yields.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc41558a