pH-sensitive DNA cleaving agents: in situactivation by ring contraction of benzo-fused cyclobutanols

pH-sensitive DNA cleaving agents: in situactivation by ring contraction of benzo-fused cyclobutanols

Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-03, Vol.49 (26), p.2622-2624
Hauptverfasser: Nagamoto, Yuuki, Hattori, Akira, Kakeya, Hideaki, Takemoto, Yoshiji, Takasu, Kiyosei
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container_end_page 2624
container_issue 26
container_start_page 2622
container_title Chemical communications (Cambridge, England)
container_volume 49
creator Nagamoto, Yuuki
Hattori, Akira
Kakeya, Hideaki
Takemoto, Yoshiji
Takasu, Kiyosei
description Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.
doi_str_mv 10.1039/c3cc39246e
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Chemical communication
title pH-sensitive DNA cleaving agents: in situactivation by ring contraction of benzo-fused cyclobutanols
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