pH-sensitive DNA cleaving agents: in situactivation by ring contraction of benzo-fused cyclobutanols

pH-sensitive DNA cleaving agents: in situactivation by ring contraction of benzo-fused cyclobutanols

Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-03, Vol.49 (26), p.2622-2624
Hauptverfasser: Nagamoto, Yuuki, Hattori, Akira, Kakeya, Hideaki, Takemoto, Yoshiji, Takasu, Kiyosei
Format: Artikel
Sprache:eng
Schlagworte:
Chemical communication
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Zusammenfassung:Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc39246e