In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing T sub(h)1 but not T sub(h)17 or T sub(h)2 cells

In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing T sub(h)1 but not T sub(h)17 or T sub(h)2 cells

In human neonates, IL-21 induces IL-10-producing T sub(h)1 cells, but inhibits T sub(h)2 and T sub(h)17 cells. In human neonates, IL-21 induces IL-10-producing T sub(h)1 cells, but inhibits T sub(h)2 and T sub(h)17 cells.

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Bibliographische Detailangaben
Veröffentlicht in:International immunology 2013-03, Vol.25 (3), p.157-169
Hauptverfasser: Doganci, Aysefa, Birkholz, Julia, Gehring, Stephan, Puhl, Alexander G, Zepp, Fred, Meyer, Claudius U
Format: Artikel
Sprache:eng
Schlagworte:
Cord blood
Helper cells
Interleukin 21
Lymphocytes T
Neonates
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Zusammenfassung:In human neonates, IL-21 induces IL-10-producing T sub(h)1 cells, but inhibits T sub(h)2 and T sub(h)17 cells. In human neonates, IL-21 induces IL-10-producing T sub(h)1 cells, but inhibits T sub(h)2 and T sub(h)17 cells.
ISSN:0953-8178
1460-2377
DOI:10.1093/intimm/dxs097