Relationship between the degeneration of the cruciate ligaments and calcium pyrophosphate dihydrate crystal deposition: anatomic, radiologic study with histologic correlation

Abstract To investigate the association of calcium pyrophosphate dihydrate (CPPD) crystal deposition and cruciate ligament (CL) degeneration, 10 cadaveric knees were studied with 1.5-T magnetic resonance imaging and sectioned in three planes. The slices were evaluated with high-resolution Faxitron radiography. The images and specimens were evaluated by two radiologists. Histologic sections were obtained from eight that contained calcifications and from two without calcifications. Radiographs and histologic analysis demonstrated CPPD crystal deposition in 80% of specimens and 75% of CLs in these eight specimens. Degenerative changes were observed in 75% of them. Such analysis demonstrated no evidence of CPPD crystals or degeneration in the control specimens.