The relationship between oral contraceptive use and sensitivity to olfactory stimuli

The present study examined differences in olfactory sensitivity between 16 naturally cycling (NC) women and 17 women taking monophasic oral contraceptives (OCs) to six odors: lemon, peppermint, rose, musk, androstenone and androsterone. Thresholds were assessed twice for both groups of women (during the periovulatory and luteal phases of their cycles) via a forced-choice discrimination task. NC women in the periovulatory phase were significantly more sensitive to androstenone, androsterone, and musk than women taking OCs. These findings give support to odor-specific hormonal modulation of olfaction. Further, due to the social and possibly sexual nature of these odors, future work should address whether there is a relationship between decreased sensitivity to these odors and reported behavioral side effects among women taking OCs. ► We assessed olfactory thresholds in users and nonusers of oral contraceptives. ► We examined olfactory thresholds for six different odors. ► We tested women in the periovulatory and luteal phases of their menstrual cycles. ► Women taking oral contraceptives are less sensitive to socially-relevant odors.