Protamine and Fertilin mRNA: Potential Biomarkers of Assisted Reproductive Technology Outcomes
We studied the relationship between the levels of protamines 1 and 2 ( PRM1 and PRM2 ) and fertilin-β ( ADAM-2 ) mRNA expression and outcomes of infertility treatment using assisted reproductive technologies was studied. Analysis of the relationships between the outcomes of in vitro fertilization an...
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Veröffentlicht in: | Bulletin of experimental biology and medicine 2012-08, Vol.153 (4), p.513-515 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | We studied the relationship between the levels of protamines 1 and 2 (
PRM1
and
PRM2
) and fertilin-β (
ADAM-2
) mRNA expression and outcomes of infertility treatment using assisted reproductive technologies was studied. Analysis of the relationships between the outcomes of
in vitro
fertilization and embryo transfer and profiles of the expression of seminal genes
PRM1
,
PRM2
,
ADAM-2
mRNA, evaluated by reverse transcription quantitative PCR was carried out in 79 couples. Significant differences in the expression of seminal
PRM1
,
PRM2
,
ADAM-2
mRNA were detected in couples with different outcomes of
in vitro
fertilization and embryo transfer. The levels of seminal gene expression are potential predictors of the efficiency of
in vitro
fertilization and embryo transfer. |
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ISSN: | 0007-4888 1573-8221 |
DOI: | 10.1007/s10517-012-1754-0 |