Research progress in understanding the mechanisms and interruption of vertical transmission of hepatitis B virus

Vertical transmission is the main route of hepatitis B virus (HBV) infection in patients with chronic hepatitis B (CHB). However, the mechanisms underlying the vertical transmission process remain to be fully elucidated. Measures to prevent mother - to - child transmission should be carried out during gestation, delivery, and the postnatal period. In order to reduce perinatal transmission and postnatal transmission through infected breast milk, newborns whose mothers tested positive for hepatitis B surface antigen (HBsAg) should be given active/passive immunization within 24 hours of delivery. In order to reduce the incidence of intrauterine transmission, pregnant women with CHB (HBV DNA greater than or equal to 10 super(6) IU/ml) should be given antiviral treatment.