Impact of Solute Carrier Family 29 Member 1 (SLC29A1) Single Nucleotide Polymorphisms on mRNA Expression in Peripheral Blood Mononuclear Cells
The effects of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphism (SNP), rs6932345 and rs747199, on SLC29A1 mRNA expression were examined. The expression levels of SLC29A1 mRNA in peripheral blood mononuclear cells (PBMCs) isolated from 46 healthy subjects (28 males and 18 fe...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2013/01/01, Vol.36(1), pp.144-146 |
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| creator | Suzuki, Yoshiharu Homma, Masato Abei, Masato Hyodo, Ichinosuke Kohda, Yukinao |
| description | The effects of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphism (SNP), rs6932345 and rs747199, on SLC29A1 mRNA expression were examined. The expression levels of SLC29A1 mRNA in peripheral blood mononuclear cells (PBMCs) isolated from 46 healthy subjects (28 males and 18 females) was compared between wild-type and mutant carriers. The mRNA levels in the rs6932345 wild-type (AA genotype) was 1.71 times that in the mutation carriers (AC/CC genotype) (p |
| doi_str_mv | 10.1248/bpb.b12-00809 |
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The expression levels of SLC29A1 mRNA in peripheral blood mononuclear cells (PBMCs) isolated from 46 healthy subjects (28 males and 18 females) was compared between wild-type and mutant carriers. The mRNA levels in the rs6932345 wild-type (AA genotype) was 1.71 times that in the mutation carriers (AC/CC genotype) (p<0.05). Similar results were observed for rs747199, because rs747199 was linked with rs6932345 at a frequency of 84.8%. It was confirmed that wild-type for rs6932345 and rs747199 showed higher SLC29A1 mRNA expression in PBMCs.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b12-00809</identifier><identifier>PMID: 23095574</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Asian Continental Ancestry Group - genetics ; Equilibrative Nucleoside Transporter 1 - genetics ; Female ; Genotype ; Humans ; Leukocytes, Mononuclear - metabolism ; Male ; mRNA expression ; Polymorphism, Single Nucleotide ; ribavirin ; RNA, Messenger - metabolism ; single nucleotide polymorphism ; solute carrier family 29A1</subject><ispartof>Biological and Pharmaceutical Bulletin, 2013/01/01, Vol.36(1), pp.144-146</ispartof><rights>2013 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c735t-cdb35905aaf8afe77563fac5a7f9e27ec74dcb3548a3fbd300a7aa2e55d3d0fb3</citedby><cites>FETCH-LOGICAL-c735t-cdb35905aaf8afe77563fac5a7f9e27ec74dcb3548a3fbd300a7aa2e55d3d0fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23095574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Yoshiharu</creatorcontrib><creatorcontrib>Homma, Masato</creatorcontrib><creatorcontrib>Abei, Masato</creatorcontrib><creatorcontrib>Hyodo, Ichinosuke</creatorcontrib><creatorcontrib>Kohda, Yukinao</creatorcontrib><creatorcontrib>Graduate School of Comprehensive Human Sciences</creatorcontrib><creatorcontrib>Department of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Department of Gastroenterology</creatorcontrib><creatorcontrib>University of Tsukuba</creatorcontrib><title>Impact of Solute Carrier Family 29 Member 1 (SLC29A1) Single Nucleotide Polymorphisms on mRNA Expression in Peripheral Blood Mononuclear Cells</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The effects of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphism (SNP), rs6932345 and rs747199, on SLC29A1 mRNA expression were examined. The expression levels of SLC29A1 mRNA in peripheral blood mononuclear cells (PBMCs) isolated from 46 healthy subjects (28 males and 18 females) was compared between wild-type and mutant carriers. The mRNA levels in the rs6932345 wild-type (AA genotype) was 1.71 times that in the mutation carriers (AC/CC genotype) (p<0.05). Similar results were observed for rs747199, because rs747199 was linked with rs6932345 at a frequency of 84.8%. It was confirmed that wild-type for rs6932345 and rs747199 showed higher SLC29A1 mRNA expression in PBMCs.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Equilibrative Nucleoside Transporter 1 - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Male</subject><subject>mRNA expression</subject><subject>Polymorphism, Single Nucleotide</subject><subject>ribavirin</subject><subject>RNA, Messenger - metabolism</subject><subject>single nucleotide polymorphism</subject><subject>solute carrier family 29A1</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxSMEotvCkSuyxKU9pPhPHDvHJWpLpW2pWDhbjjPpeuXEwU4k9kvwmfF2yyJx4TKWZ3568-yXZe8IviS0kB-bsblsCM0xlrh6kS0IK0TOKeEvswWuiMxLwuVJdhrjFmMsMGWvsxPKcMW5KBbZr9t-1GZCvkNr7-YJUK1DsBDQte6t2yFaoTvom9Qg6Hy9qmm1JBdobYdHB-h-Ng78ZFtAD97teh_GjY19RH5A_df7Jbr6OQaI0aa7HdADBDtuIGiHPjnvW3TnBz_sNXRANTgX32SvOu0ivH0-z7Lv11ff6s_56svNbb1c5UYwPuWmbRivMNe6k7oDIXjJOm24Fl0FVIARRWsSUkjNuqZlGGuhNQXOW9birmFn2flBdwz-xwxxUr2NJjnQA_g5KsIok-lLhfw_SgVjkjDOEvrhH3Tr5zCkhyhSCImJlAInKj9QJvgYA3RqDLbXYacIVvtMVcpUpUzVU6aJf_-sOjc9tEf6T4gJuDkAaWqNdn5wdoC_u00UjfXOK4oJS6KsxERhyhUmRbEvJakIZSVPSvVBaRsn_QjHVTpMNqX0ZIyViuzL0eBxajY6KBjYb_H8yn8</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Suzuki, Yoshiharu</creator><creator>Homma, Masato</creator><creator>Abei, Masato</creator><creator>Hyodo, Ichinosuke</creator><creator>Kohda, Yukinao</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20130101</creationdate><title>Impact of Solute Carrier Family 29 Member 1 (SLC29A1) Single Nucleotide Polymorphisms on mRNA Expression in Peripheral Blood Mononuclear Cells</title><author>Suzuki, Yoshiharu ; Homma, Masato ; Abei, Masato ; Hyodo, Ichinosuke ; Kohda, Yukinao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c735t-cdb35905aaf8afe77563fac5a7f9e27ec74dcb3548a3fbd300a7aa2e55d3d0fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Equilibrative Nucleoside Transporter 1 - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Male</topic><topic>mRNA expression</topic><topic>Polymorphism, Single Nucleotide</topic><topic>ribavirin</topic><topic>RNA, Messenger - metabolism</topic><topic>single nucleotide polymorphism</topic><topic>solute carrier family 29A1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Yoshiharu</creatorcontrib><creatorcontrib>Homma, Masato</creatorcontrib><creatorcontrib>Abei, Masato</creatorcontrib><creatorcontrib>Hyodo, Ichinosuke</creatorcontrib><creatorcontrib>Kohda, Yukinao</creatorcontrib><creatorcontrib>Graduate School of Comprehensive Human Sciences</creatorcontrib><creatorcontrib>Department of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Department of Gastroenterology</creatorcontrib><creatorcontrib>University of Tsukuba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Yoshiharu</au><au>Homma, Masato</au><au>Abei, Masato</au><au>Hyodo, Ichinosuke</au><au>Kohda, Yukinao</au><aucorp>Graduate School of Comprehensive Human Sciences</aucorp><aucorp>Department of Pharmaceutical Sciences</aucorp><aucorp>Department of Gastroenterology</aucorp><aucorp>University of Tsukuba</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Solute Carrier Family 29 Member 1 (SLC29A1) Single Nucleotide Polymorphisms on mRNA Expression in Peripheral Blood Mononuclear Cells</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>36</volume><issue>1</issue><spage>144</spage><epage>146</epage><pages>144-146</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The effects of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphism (SNP), rs6932345 and rs747199, on SLC29A1 mRNA expression were examined. The expression levels of SLC29A1 mRNA in peripheral blood mononuclear cells (PBMCs) isolated from 46 healthy subjects (28 males and 18 females) was compared between wild-type and mutant carriers. The mRNA levels in the rs6932345 wild-type (AA genotype) was 1.71 times that in the mutation carriers (AC/CC genotype) (p<0.05). Similar results were observed for rs747199, because rs747199 was linked with rs6932345 at a frequency of 84.8%. It was confirmed that wild-type for rs6932345 and rs747199 showed higher SLC29A1 mRNA expression in PBMCs.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>23095574</pmid><doi>10.1248/bpb.b12-00809</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Asian Continental Ancestry Group - genetics Equilibrative Nucleoside Transporter 1 - genetics Female Genotype Humans Leukocytes, Mononuclear - metabolism Male mRNA expression Polymorphism, Single Nucleotide ribavirin RNA, Messenger - metabolism single nucleotide polymorphism solute carrier family 29A1 |
| title | Impact of Solute Carrier Family 29 Member 1 (SLC29A1) Single Nucleotide Polymorphisms on mRNA Expression in Peripheral Blood Mononuclear Cells |
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