Impact of Solute Carrier Family 29 Member 1 (SLC29A1) Single Nucleotide Polymorphisms on mRNA Expression in Peripheral Blood Mononuclear Cells

The effects of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphism (SNP), rs6932345 and rs747199, on SLC29A1 mRNA expression were examined. The expression levels of SLC29A1 mRNA in peripheral blood mononuclear cells (PBMCs) isolated from 46 healthy subjects (28 males and 18 fe...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2013/01/01, Vol.36(1), pp.144-146
Hauptverfasser:	Suzuki, Yoshiharu, Homma, Masato, Abei, Masato, Hyodo, Ichinosuke, Kohda, Yukinao
Format:	Artikel
Sprache:	eng
Schlagworte:	Asian Continental Ancestry Group - genetics Equilibrative Nucleoside Transporter 1 - genetics Female Genotype Humans Leukocytes, Mononuclear - metabolism Male mRNA expression Polymorphism, Single Nucleotide ribavirin RNA, Messenger - metabolism single nucleotide polymorphism solute carrier family 29A1
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Zusammenfassung:	The effects of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphism (SNP), rs6932345 and rs747199, on SLC29A1 mRNA expression were examined. The expression levels of SLC29A1 mRNA in peripheral blood mononuclear cells (PBMCs) isolated from 46 healthy subjects (28 males and 18 females) was compared between wild-type and mutant carriers. The mRNA levels in the rs6932345 wild-type (AA genotype) was 1.71 times that in the mutation carriers (AC/CC genotype) (p
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.b12-00809