Phase I Dose-Escalation Study of Stereotactic Body Radiotherapy in Patients With Hepatic Metastases

Purpose To identify a tolerable and effective dose for 5-fraction stereotactic body radiotherapy for hepatic metastases. Methods Patients were enrolled onto three dose-escalation cohorts: 30 Gy in 3 fractions, 50 Gy in 5 fractions, and 60 Gy in 5 fractions. Eligible patients had one to five hepatic...

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Veröffentlicht in:	Annals of surgical oncology 2011-04, Vol.18 (4), p.1081-1087
Hauptverfasser:	Rule, William, Timmerman, Robert, Tong, Liyue, Abdulrahman, Ramzi, Meyer, Jeffrey, Boike, Thomas, Schwarz, Roderich E., Weatherall, Paul, Chinsoo Cho, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Dose Fractionation Female Follow-Up Studies Hepatobiliary Tumors Humans Liver - pathology Liver - surgery Liver Neoplasms - secondary Liver Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Neoplasms - pathology Neoplasms - surgery Oncology Radiosurgery Radiotherapy Dosage Surgery Surgical Oncology Survival Rate Treatment Outcome
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Zusammenfassung:	Purpose To identify a tolerable and effective dose for 5-fraction stereotactic body radiotherapy for hepatic metastases. Methods Patients were enrolled onto three dose-escalation cohorts: 30 Gy in 3 fractions, 50 Gy in 5 fractions, and 60 Gy in 5 fractions. Eligible patients had one to five hepatic metastases, ability to spare a critical hepatic volume (volume receiving
ISSN:	1068-9265 1534-4681
DOI:	10.1245/s10434-010-1405-5