Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid
► Hyaluronic acid and POSS nanaoparticals can form reversible pH-induced aggregates. ► Micelles, sacs and membranes have been observed in this hybrid system. ► Sac after defect can be resealed by triggering additional self-assembly. ► The self-sealing macroscopic structure offer opportunities in man...
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| Veröffentlicht in: | Carbohydrate polymers 2013-04, Vol.94 (1), p.444-448 |
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| creator | Lu, Lu Zhang, Chaowen Li, Lihua Zhou, Changren |
| description | ► Hyaluronic acid and POSS nanaoparticals can form reversible pH-induced aggregates. ► Micelles, sacs and membranes have been observed in this hybrid system. ► Sac after defect can be resealed by triggering additional self-assembly. ► The self-sealing macroscopic structure offer opportunities in many areas.
We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors. |
| doi_str_mv | 10.1016/j.carbpol.2013.01.061 |
| format | Article |
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We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2013.01.061</identifier><identifier>PMID: 23544561</identifier><identifier>CODEN: CAPOD8</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Applied sciences ; drugs ; Exact sciences and technology ; gene transfer ; Hyaluronic acid ; Hyaluronic Acid - chemistry ; hydrogen bonding ; Hydrogen-Ion Concentration ; Inorganic and organomineral polymers ; Micelles ; Natural polymers ; Nephelometry and Turbidimetry ; Organic/inorganic hybrid material ; Organosilicon Compounds - chemistry ; Particle Size ; pH-responsive ; Physicochemistry of polymers ; POSS ; Properties and characterization ; Self-assembly ; Starch and polysaccharides ; tertiary amines</subject><ispartof>Carbohydrate polymers, 2013-04, Vol.94 (1), p.444-448</ispartof><rights>2013 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-18c8625c168a33625084a5914df1e3c37bc80b16d8f2ad7cbc4182e6083b14e23</citedby><cites>FETCH-LOGICAL-c419t-18c8625c168a33625084a5914df1e3c37bc80b16d8f2ad7cbc4182e6083b14e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2013.01.061$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27239340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23544561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Lu</creatorcontrib><creatorcontrib>Zhang, Chaowen</creatorcontrib><creatorcontrib>Li, Lihua</creatorcontrib><creatorcontrib>Zhou, Changren</creatorcontrib><title>Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>► Hyaluronic acid and POSS nanaoparticals can form reversible pH-induced aggregates. ► Micelles, sacs and membranes have been observed in this hybrid system. ► Sac after defect can be resealed by triggering additional self-assembly. ► The self-sealing macroscopic structure offer opportunities in many areas.
We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors.</description><subject>Applied sciences</subject><subject>drugs</subject><subject>Exact sciences and technology</subject><subject>gene transfer</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - chemistry</subject><subject>hydrogen bonding</subject><subject>Hydrogen-Ion Concentration</subject><subject>Inorganic and organomineral polymers</subject><subject>Micelles</subject><subject>Natural polymers</subject><subject>Nephelometry and Turbidimetry</subject><subject>Organic/inorganic hybrid material</subject><subject>Organosilicon Compounds - chemistry</subject><subject>Particle Size</subject><subject>pH-responsive</subject><subject>Physicochemistry of polymers</subject><subject>POSS</subject><subject>Properties and characterization</subject><subject>Self-assembly</subject><subject>Starch and polysaccharides</subject><subject>tertiary amines</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEotvCIwC-IHFJ8NiO45xQVUGLVKmIpWfLcSZbr7xxsJOVlqfHq13giC_jw_fPjD8XxRugFVCQH7eVNbGbgq8YBV5RqKiEZ8UKVNOWwIV4XqwoCFEqCc1FcZnSluYjgb4sLhivhaglrAr3HfcYk-s8kumujJimMCa3R2I2m4gbM2MinUnYkzCS-QlJQj-UJiXcdf5AwkCGZbSzC6Px7lfGvj2s18SMPXk6GL_EMDpLjHX9q-LFYHzC1-d6VTx--fzj5q68f7j9enN9X1oB7VyCskqy2oJUhvN8o0qYugXRD4Dc8qazinYgezUw0ze2yzHFUFLFOxDI-FXx4dR3iuHngmnWO5csem9GDEvSwBlnirYAGa1PqI0hpYiDnqLbmXjQQPXRst7qs2V9tKwp6Gww596eRyzdDvu_qT9aM_D-DJhkjR-iGa1L_7iG8ZYLmrl3J24wQZtNzMzjOk-S-adq1vLjaz6dCMzK9g6jTtbhaLF3Ee2s--D-s-xv4oSmoQ</recordid><startdate>20130415</startdate><enddate>20130415</enddate><creator>Lu, Lu</creator><creator>Zhang, Chaowen</creator><creator>Li, Lihua</creator><creator>Zhou, Changren</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130415</creationdate><title>Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid</title><author>Lu, Lu ; Zhang, Chaowen ; Li, Lihua ; Zhou, Changren</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-18c8625c168a33625084a5914df1e3c37bc80b16d8f2ad7cbc4182e6083b14e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Applied sciences</topic><topic>drugs</topic><topic>Exact sciences and technology</topic><topic>gene transfer</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - chemistry</topic><topic>hydrogen bonding</topic><topic>Hydrogen-Ion Concentration</topic><topic>Inorganic and organomineral polymers</topic><topic>Micelles</topic><topic>Natural polymers</topic><topic>Nephelometry and Turbidimetry</topic><topic>Organic/inorganic hybrid material</topic><topic>Organosilicon Compounds - chemistry</topic><topic>Particle Size</topic><topic>pH-responsive</topic><topic>Physicochemistry of polymers</topic><topic>POSS</topic><topic>Properties and characterization</topic><topic>Self-assembly</topic><topic>Starch and polysaccharides</topic><topic>tertiary amines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Lu</creatorcontrib><creatorcontrib>Zhang, Chaowen</creatorcontrib><creatorcontrib>Li, Lihua</creatorcontrib><creatorcontrib>Zhou, Changren</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Lu</au><au>Zhang, Chaowen</au><au>Li, Lihua</au><au>Zhou, Changren</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2013-04-15</date><risdate>2013</risdate><volume>94</volume><issue>1</issue><spage>444</spage><epage>448</epage><pages>444-448</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><coden>CAPOD8</coden><abstract>► Hyaluronic acid and POSS nanaoparticals can form reversible pH-induced aggregates. ► Micelles, sacs and membranes have been observed in this hybrid system. ► Sac after defect can be resealed by triggering additional self-assembly. ► The self-sealing macroscopic structure offer opportunities in many areas.
We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23544561</pmid><doi>10.1016/j.carbpol.2013.01.061</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Applied sciences drugs Exact sciences and technology gene transfer Hyaluronic acid Hyaluronic Acid - chemistry hydrogen bonding Hydrogen-Ion Concentration Inorganic and organomineral polymers Micelles Natural polymers Nephelometry and Turbidimetry Organic/inorganic hybrid material Organosilicon Compounds - chemistry Particle Size pH-responsive Physicochemistry of polymers POSS Properties and characterization Self-assembly Starch and polysaccharides tertiary amines |
| title | Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid |
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