Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid

► Hyaluronic acid and POSS nanaoparticals can form reversible pH-induced aggregates. ► Micelles, sacs and membranes have been observed in this hybrid system. ► Sac after defect can be resealed by triggering additional self-assembly. ► The self-sealing macroscopic structure offer opportunities in many areas. We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors.