Portable optical-resolution photoacoustic microscopy with a pulsed laser diode excitation
Optical-resolution photoacoustic microscopy (OR-PAM) has been significantly improved in terms of spatial resolution, detection sensitivity, imaging speed, and penetration depth. However, the popular producibility of OR-PAM system is still limited by the size and cost of solid-state laser excitation....
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| Veröffentlicht in: | Applied physics letters 2013-02, Vol.102 (5) |
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| container_title | Applied physics letters |
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| creator | Zeng, Lvming Liu, Guodong Yang, Diwu Ji, Xuanrong |
| description | Optical-resolution photoacoustic microscopy (OR-PAM) has been significantly improved in terms of spatial resolution, detection sensitivity, imaging speed, and penetration depth. However, the popular producibility of OR-PAM system is still limited by the size and cost of solid-state laser excitation. Here, we developed a portable laser-diode-based OR-PAM (LD-OR-PAM) system using a pulsed semiconductor laser source, which was operated at 905 ± 15 nm with a pulse energy as low as 4.9 μJ. The measured lateral resolution has been improved to ∼1.5 μm from hundreds of microns. The compact and inexpensive natures of LD-OR-PAM would promote the potential clinical applications such as in dermatology. |
| doi_str_mv | 10.1063/1.4791566 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Applied physics letters, 2013-02, Vol.102 (5) |
| issn | 0003-6951 1077-3118 |
| language | eng |
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| source | AIP Journals Complete; AIP Digital Archive; Alma/SFX Local Collection |
| subjects | Diodes Energy use Excitation Photoacoustic microscopy Portability Pulsed lasers Semiconductor lasers Solid state lasers |
| title | Portable optical-resolution photoacoustic microscopy with a pulsed laser diode excitation |
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