Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials

Objective To evaluate the usefulness of preimplantation genetic screening (PGS) using fluorescence in situ hybridization (FISH) for two different indications: repetitive implantation failure (RIF) and advanced maternal age (AMA). Design Two prospective, randomized controlled trials with patients all...

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Veröffentlicht in:	Fertility and sterility 2013-04, Vol.99 (5), p.1400-1407
Hauptverfasser:	Rubio, Carmen, Ph.D, Bellver, José, M.D., Ph.D, Rodrigo, Lorena, M.Sc, Bosch, Ernesto, M.D., Ph.D, Mercader, Amparo, Ph.D, Vidal, Carmen, M.D., Ph.D, De los Santos, Maria José, Ph.D, Giles, Juan, M.D, Labarta, Elena, M.D, Domingo, Javier, M.D, Crespo, Juana, M.D, Remohí, José, M.D., Ph.D, Pellicer, Antonio, M.D., Ph.D, Simón, Carlos, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult advanced maternal age Aneuploidy biopsy blastocyst chromosomes confidence interval Embryo Culture Techniques Embryo Implantation Embryo Transfer - methods Female fluorescence in situ hybridization Genetic Testing - methods Humans In Situ Hybridization, Fluorescence - methods Infertility, Female - therapy Internal Medicine intracytoplasmic sperm injection live birth rate Maternal Age Obstetrics and Gynecology odds ratio patients PGS Pregnancy Pregnancy Rate Preimplantation Diagnosis - methods Prospective Studies randomized clinical trials repetitive implantation failure screening Treatment Failure women
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Beschreibung
Zusammenfassung:	Objective To evaluate the usefulness of preimplantation genetic screening (PGS) using fluorescence in situ hybridization (FISH) for two different indications: repetitive implantation failure (RIF) and advanced maternal age (AMA). Design Two prospective, randomized controlled trials with patients allocated in two arms: blastocyst transfer on day 5 (group A) or PGS with transfer on day 5 (group B). Setting University-affiliated private clinics. Patient(s) The RIF study included women
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2012.11.041