Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects
Highlights ► Role of extrasynaptic GluN2B subunit-containing NMDA receptors in excitotoxicity. ► Role of synaptic GluN2A subunit-containing NMDA receptors in neuroprotection. ► Effect of fluoxetine. ► Clinical studies with different glutamate receptor antagonists. ► Selective GluN2B subunit-containi...
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| Veröffentlicht in: | Brain research bulletin 2013-04, Vol.93, p.32-38 |
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| container_title | Brain research bulletin |
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| creator | Vizi, E.S Kisfali, M Lőrincz, T |
| description | Highlights ► Role of extrasynaptic GluN2B subunit-containing NMDA receptors in excitotoxicity. ► Role of synaptic GluN2A subunit-containing NMDA receptors in neuroprotection. ► Effect of fluoxetine. ► Clinical studies with different glutamate receptor antagonists. ► Selective GluN2B subunit-containing NMDA receptor antagonists. |
| doi_str_mv | 10.1016/j.brainresbull.2012.10.005 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 2013-04, Vol.93, p.32-38 |
| issn | 0361-9230 1873-2747 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Brain Injuries - drug therapy Brain Injuries - metabolism Brain Injuries - pathology Calcium - metabolism Excitotoxicity Extrasynaptic receptors Fluoxetine - therapeutic use GluN2A GluN2B Humans Models, Biological Neurology Neuroprotection Neuroprotective Agents - therapeutic use Nonsynaptic ionotropic receptors Receptors, N-Methyl-D-Aspartate - metabolism Synapses - drug effects Synapses - metabolism |
| title | Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects |
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