Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects

Highlights ► Role of extrasynaptic GluN2B subunit-containing NMDA receptors in excitotoxicity. ► Role of synaptic GluN2A subunit-containing NMDA receptors in neuroprotection. ► Effect of fluoxetine. ► Clinical studies with different glutamate receptor antagonists. ► Selective GluN2B subunit-containi...

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Veröffentlicht in:	Brain research bulletin 2013-04, Vol.93, p.32-38
Hauptverfasser:	Vizi, E.S, Kisfali, M, Lőrincz, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Injuries - drug therapy Brain Injuries - metabolism Brain Injuries - pathology Calcium - metabolism Excitotoxicity Extrasynaptic receptors Fluoxetine - therapeutic use GluN2A GluN2B Humans Models, Biological Neurology Neuroprotection Neuroprotective Agents - therapeutic use Nonsynaptic ionotropic receptors Receptors, N-Methyl-D-Aspartate - metabolism Synapses - drug effects Synapses - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► Role of extrasynaptic GluN2B subunit-containing NMDA receptors in excitotoxicity. ► Role of synaptic GluN2A subunit-containing NMDA receptors in neuroprotection. ► Effect of fluoxetine. ► Clinical studies with different glutamate receptor antagonists. ► Selective GluN2B subunit-containing NMDA receptor antagonists.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2012.10.005