Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow Microreactors

Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N‐fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron‐withdrawing, an electron‐donating, and a sterically hindered functional group in good yields.