ROS Links Glucose Metabolism to Breast Cancer Stem Cell and EMT Phenotype

ROS Links Glucose Metabolism to Breast Cancer Stem Cell and EMT Phenotype

Cancer stem cells display an epithelial-mesenchymal transition phenotype and are resistant to current therapies. In this issue of Cancer Cell, Dong and colleagues demonstrate that these phenotypes in basal-like breast cancer are promoted by a metabolic switch to glucose metabolism, resulting in decr...

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Veröffentlicht in:Cancer cell 2013-03, Vol.23 (3), p.265-267
Hauptverfasser: Schieber, Michael S., Chandel, Navdeep S.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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Zusammenfassung:Cancer stem cells display an epithelial-mesenchymal transition phenotype and are resistant to current therapies. In this issue of Cancer Cell, Dong and colleagues demonstrate that these phenotypes in basal-like breast cancer are promoted by a metabolic switch to glucose metabolism, resulting in decreased reactive oxygen species levels.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2013.02.021