Antiplasmodial Activity of Compounds from the Surface Exudates of Senecio roseiflorus

From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to goo...

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Veröffentlicht in:	Natural product communications 2013-02, Vol.8 (2), p.175-176
Hauptverfasser:	Kerubo, Leonidah Omosa, Midiwo, Jacob Ogweno, Derese, Solomon, Langat, Moses K., Akala, Hosea M., Waters, Norman C., Peter, Martin, Heydenreich, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - isolation & purification Antimalarials - pharmacology Flavonoids - isolation & purification Flavonoids - pharmacology Plasmodium falciparum - drug effects Senecio - chemistry
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Zusammenfassung:	From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4′-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 ± 0.8 and 4.4 ± 0.01 μg/mL respectively.
ISSN:	1934-578X 1555-9475
DOI:	10.1177/1934578X1300800210