Diagnostic and prognostic significance of CA IX and suPAR in gastric cancer

This study was intended to evaluate the prognostic and diagnostic significance of carbonic anhydrase IX (CA IX) and soluble urokinase plasminogen activator receptor (suPAR) levels in gastric cancer patients. CA IX and suPAR were analyzed from serum and plasma samples of gastric cancer patients. Fift...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 2013-06, Vol.30 (2), p.540-540, Article 540
Hauptverfasser:	Fidan, Evren, Mentese, Ahmet, Ozdemir, Feyyaz, Deger, Orhan, Kavgaci, Halil, Caner Karahan, S., Aydin, Fazil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - blood Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - blood Carbonic Anhydrase IX Carbonic Anhydrases - biosynthesis Carbonic Anhydrases - blood Case-Control Studies Female Hematology Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Oncology Original Paper Pathology Prognosis Receptors, Urokinase Plasminogen Activator - biosynthesis Receptors, Urokinase Plasminogen Activator - blood Stomach Neoplasms - blood Stomach Neoplasms - diagnosis Stomach Neoplasms - mortality Survival Rate - trends Up-Regulation - genetics
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Zusammenfassung:	This study was intended to evaluate the prognostic and diagnostic significance of carbonic anhydrase IX (CA IX) and soluble urokinase plasminogen activator receptor (suPAR) levels in gastric cancer patients. CA IX and suPAR were analyzed from serum and plasma samples of gastric cancer patients. Fifty patients and 34 controls were enrolled. CA IX and suPAR levels were statistically significantly higher in the patient group (patient; 182.5 ± 212.4, control; 47.3 ± 32, P = 0.0001 and patient; 5.74 ± 5.3, control; 2.27 ± 0.77, P = 0.0001, respectively). CA IX and suPAR levels were higher in metastatic subjects (metastatic; 227.1 ± 273.5, non-metastatic; 147.4 ± 144.1, P > 0.05). Prognosis was worse in the patient group with elevated suPAR. CA IX and especially suPAR are correlated with the presence and stage of the disease. High suPAR levels indicate a poorer prognosis in gastric cancer patients.
ISSN:	1357-0560 1559-131X
DOI:	10.1007/s12032-013-0540-9