Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR

In the commonly used nucleation-dependent model of protein aggregation, aggregation proceeds only after a lag phase in which the concentration of energetically unfavorable nuclei reaches a critical value. The formation of oligomeric species prior to aggregation can be difficult to detect by current...

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Veröffentlicht in:	Biochemistry (Easton) 2013-03, Vol.52 (11), p.1903
Hauptverfasser:	Suzuki, Yuta, Brender, Jeffrey R, Soper, Molly T, Krishnamoorthy, Janarthanan, Zhou, Yunlong, Ruotolo, Brandon T, Kotov, Nicholas A, Ramamoorthy, Ayyalusamy, Marsh, E Neil G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - ultrastructure Circular Dichroism Humans Methionine - analogs & derivatives Methionine - chemistry Microscopy, Atomic Force Nuclear Magnetic Resonance, Biomolecular Peptide Fragments - chemistry Peptide Fragments - ultrastructure Protein Structure, Secondary Solubility
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