Low serum fetuin A levels and incident stroke in patients with maintenance haemodialysis

Background and objectives Fetuin A, a predictor of mortality in dialysis patients, is associated with vascular calcification and atherosclerosis in haemodialysis (HD) patients. Whether it predicts stroke remains unknown. This study aimed to investigate the association between fetuin A and incident stoke in maintenance HD patients. Design, setting, participants and measurements This is a prospective observational study. 238 prevalent HD patients (127 women and 111 men; mean age, 60 ± 12 years) were followed up for the occurrence of stroke for 55 months. Baseline circulating fetuin A levels, biochemical data and other markers of inflammation were measured. The major outcome was the occurrence of incident ischaemic or haemorrhagic stroke. Results Thirty one patients had incident strokes; an incidence of 38·4/1000 patient‐years (95% confidence interval (CI) 36·5–39·8/1000 patient‐years) on follow‐up. Patients in the lowest tertile of fetuin A concentration had highest risk to have incident stroke (P