The Role of Immunohistochemistry in Breast Cancer Patients Treated With Neoadjuvant Chemotherapy: An Old Tool With an Enduring Prognostic Value

Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemotherapy is a potential surrogate for survival. We defined molecular subtypes determined by hormonal receptors (HR) and human epidermal growth factor receptor 2 (HER2) status. pCR was significantly higher in patients with HR− /HER2...

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Veröffentlicht in:	Clinical breast cancer 2013-04, Vol.13 (2), p.146-152
Hauptverfasser:	Sánchez-Muñoz, Alfonso, Plata-Fernández, Yessica Maria, Fernández, Margarita, Jaén-Morago, Ana, Fernández-Navarro, Monica, de la Torre-Cabrera, Capilla, Ramirez-Tortosa, Cesar, Lomas-Garrido, Maria, Llácer, Casilda, Navarro-Perez, Victor, Alba-Conejo, Emilio, Sánchez-Rovira, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - metabolism Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - mortality Carcinoma, Lobular - drug therapy Carcinoma, Lobular - metabolism Carcinoma, Lobular - mortality Cyclophosphamide - administration & dosage Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Doxorubicin - administration & dosage Epirubicin - administration & dosage Female Follow-Up Studies Hematology, Oncology and Palliative Medicine Humans Immunoenzyme Techniques Ki-67 Antigen - metabolism Ki-67 marker Middle Aged Molecular subtypes Neoadjuvant chemotherapy Neoadjuvant Therapy Neoplasm Staging Obstetrics and Gynecology Outcome Paclitaxel - administration & dosage Pathologic complete response Prognosis Prospective Studies Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Remission Induction Retrospective Studies Survival Rate Young Adult
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Zusammenfassung:	Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemotherapy is a potential surrogate for survival. We defined molecular subtypes determined by hormonal receptors (HR) and human epidermal growth factor receptor 2 (HER2) status. pCR was significantly higher in patients with HR− /HER2− and in HR− /HER2+ breast cancer treated with dose-dense neoadjuvant chemotherapy. Molecular subtypes, pCR, and the Ki-67 proliferative marker were independent prognostic factors for disease-free survival and overall survival.
ISSN:	1526-8209 1938-0666
DOI:	10.1016/j.clbc.2012.11.006