Effect of Ouabain on Growth of Skin Explants in Organotypic Culture

Organotypic culture was used to study the effects of glycoside ouabain and its aglycone ouabagenin on the growth of skin explants from 10-12-day chicken embryos. The tested agents demonstrated dose-dependent inhibition of skin growth. The effective concentrations imply that ouabain and ouabagenin me...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2013-02, Vol.154 (4), p.419-420
Hauptverfasser:	Penniyaynen, V. A., Kipenko, A. V., Lopatina, E. V., Krylov, B. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Biology Chick Embryo Growth Internal Medicine Laboratory Medicine Ouabain Ouabain - analogs & derivatives Ouabain - pharmacology Pathology Skin Skin - drug effects Skin - embryology Skin - enzymology Sodium-Potassium-Exchanging ATPase - metabolism
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Beschreibung
Zusammenfassung:	Organotypic culture was used to study the effects of glycoside ouabain and its aglycone ouabagenin on the growth of skin explants from 10-12-day chicken embryos. The tested agents demonstrated dose-dependent inhibition of skin growth. The effective concentrations imply that ouabain and ouabagenin mediate their inhibitory effect on the skin growth via interaction with α1-isoform of Na + ,K + -ATPase that plays mostly the role of ionic pump.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-013-1965-z