Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans

Highlights ► Oral immunization with rAd elicits γ-IFN and granzyme B producing T cells in humans ► Granzyme B responses can be boosted with oral immunization ► Oral immunization with rAd has a positive safety profile ► Oral immunization with rAd does not elicit substantial anti-vector antibody respo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2013-03, Vol.31 (13), p.1752-1758
Hauptverfasser:	Peters, Wendy, Brandl, Jennifer R, Lindbloom, Jonathan D, Martinez, C. Josefina, Scallan, Ciaran D, Trager, George R, Tingley, Debora W, Kabongo, Martin L, Tucker, Sean N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Administration, Oral Adult Allergy and Immunology Animals antigens Applied microbiology Avian influenza Biological and medical sciences clinical trials cytotoxicity Drug Carriers - administration & dosage Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - pathology Enzyme-Linked Immunospot Assay Female Fundamental and applied biological sciences. Psychology Genetic Vectors Granzymes - metabolism Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology hemagglutinins Humans immune response Influenza Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - genetics Influenza Vaccines - immunology Influenza, Human - prevention & control interferon-gamma Interferon-gamma - secretion Male Microbiology Miscellaneous Mucosal oral administration Placebos - administration & dosage Recombinant adenovirus T-lymphocytes T-Lymphocytes - immunology TLR3 ligand Toll-Like Receptor 3 - agonists Toll-Like Receptor 3 - genetics vaccination vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Oral immunization with rAd elicits γ-IFN and granzyme B producing T cells in humans ► Granzyme B responses can be boosted with oral immunization ► Oral immunization with rAd has a positive safety profile ► Oral immunization with rAd does not elicit substantial anti-vector antibody responses.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.01.023