Broadening the catalyst and reaction scope of regio- and chemoselective C-H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(II) and Ru(II) catalysis

Broadening the catalyst and reaction scope of regio- and chemoselective C-H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(II) and Ru(II) catalysis

A unique Rh(II) and Ru(II) catalyzed C-H oxygenation of aryl ketones and other arenes has been developed for the facile synthesis of diverse functionalized phenols. The reaction demonstrates excellent reactivity, regio- and chemoselectivity, good functional group compatibility and high yields. The p...

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Veröffentlicht in:Organic & biomolecular chemistry 2013-04, Vol.11 (14), p.2318-2322
Hauptverfasser: Shan, Gang, Han, Xuesong, Lin, Yun, Yu, Shanyou, Rao, Yu
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Catalysis
Ketones - chemistry
Molecular Structure
Oxygen - chemistry
Phenols - chemistry
Rhodium - chemistry
Ruthenium - chemistry
Stereoisomerism
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Zusammenfassung:A unique Rh(II) and Ru(II) catalyzed C-H oxygenation of aryl ketones and other arenes has been developed for the facile synthesis of diverse functionalized phenols. The reaction demonstrates excellent reactivity, regio- and chemoselectivity, good functional group compatibility and high yields. The practicality of this method has been proved by gram-scale synthesis of a few different 2-acylphenols. Its utility has been well exemplified in further applications in heterocycle synthesis and direct modifications of drug Fenofibrate.
ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob27457h