Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines

Highlights ► We examine the impact of Hsp90 inhibitors on the invasion and migration capacity of tumor cells. ► Hsp90 inhibitors act anti-metastatically under normoxia and hypoxia. ► Combined drug-radiation treatment inhibits cell invasion to a much greater extent. ► Hsp90 inhibitors deplete several...

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Veröffentlicht in:	Cancer letters 2013-05, Vol.331 (2), p.200-210
Hauptverfasser:	Hartmann, Susanne, Günther, Nadine, Biehl, Marlene, Katzer, Astrid, Kuger, Sebastian, Worschech, Eike, Sukhorukov, Vladimir L, Krohne, Georg, Zimmermann, Heiko, Flentje, Michael, Djuzenova, Cholpon S
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actin remodeling Angiogenesis Apoptosis Binding sites Biomedical research Blotting, Western Brain Neoplasms - pathology Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - pathology Cell adhesion Cell culture Cell cycle Cell Hypoxia cell invasion Cell Line, Tumor Cell matrix Cell Movement - drug effects Colleges & universities Drug dosages drugs Flow Cytometry Glioblastoma - pathology Hematology, Oncology and Palliative Medicine HSP90 Heat-Shock Proteins - antagonists & inhibitors Humans Hypoxia ionizing radiation Isoxazoles - pharmacology lung neoplasms Lung Neoplasms - pathology Metastasis Microscopy Microscopy, Electron, Scanning Morphology Motility Neoplasm Invasiveness - prevention & control normoxia oxygen Proteins Pyrimidines - pharmacology Radiation Radiation therapy Resorcinols - pharmacology Stress fibers Wound healing Wound Healing - drug effects
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Zusammenfassung:	Highlights ► We examine the impact of Hsp90 inhibitors on the invasion and migration capacity of tumor cells. ► Hsp90 inhibitors act anti-metastatically under normoxia and hypoxia. ► Combined drug-radiation treatment inhibits cell invasion to a much greater extent. ► Hsp90 inhibitors deplete several marker proteins and impair the F-actin modulation. ► A mechanism for the drug-IR mediated inhibition of cell migration is proposed.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2012.12.027