Pd(II)-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation

Pd(II)-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation

A palladium-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation is described. This protocol provides efficient access to a range of ortho-acyl phenylacetamides, which can be easily converted to 3-isochromanone derivatives.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (16), p.1654-1656
Hauptverfasser: Park, Jihye, Kim, Minyoung, Sharma, Satyasheel, Park, Eonjeong, Kim, Aejin, Lee, Sang Hwi, Kwak, Jong Hwan, Jung, Young Hoon, Kim, In Su
Format: Artikel
Sprache:eng
Schlagworte:
Acetamides - chemistry
Activation
Acylation
Bonding
Carboxylic Acids - chemistry
Catalysis
Chromones - chemical synthesis
Chromones - chemistry
Decarboxylation
Derivatives
Molecular Structure
Organometallic Compounds - chemistry
Palladium - chemistry
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Zusammenfassung:A palladium-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation is described. This protocol provides efficient access to a range of ortho-acyl phenylacetamides, which can be easily converted to 3-isochromanone derivatives.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc38764j