Gold catalyzed stereoselective tandem hydroamination-formal aza-Diels-Alder reaction of propargylic amino esters

Gold catalyzed stereoselective tandem hydroamination-formal aza-Diels-Alder reaction of propargylic amino esters

A gold-catalyzed tandem intramolecular hydroamination-formal aza-Diels-Alder reaction of propargylic amino esters is described. The overall process leads to the formation of a tetracyclic framework as a single diastereoisomer, with the creation of four bonds and five stereocenters.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-02, Vol.49 (13), p.1336-1338
Hauptverfasser: Fustero, Santos, Bello, Paula, Miró, Javier, Sánchez-Roselló, María, Maestro, Miguel A, González, Javier, del Pozo, Carlos
Format: Artikel
Sprache:eng
Schlagworte:
Chemical bonds
Esters
Gold
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Zusammenfassung:A gold-catalyzed tandem intramolecular hydroamination-formal aza-Diels-Alder reaction of propargylic amino esters is described. The overall process leads to the formation of a tetracyclic framework as a single diastereoisomer, with the creation of four bonds and five stereocenters.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc37796a