Corrigendum: Global quantification of mammalian gene expression control

[...]the estimated maximum translation rate constant in sea urchin embryos at 15 uC (140 proteins per mRNA per hour) is lower than our corrected prediction for mouse fibroblasts (1,000 proteins per mRNA per hour). Overall, copy number estimates of the eight proteins obtained by alternative approache...

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Veröffentlicht in:Nature (London) 2013-03, Vol.495 (7439), p.126
Hauptverfasser: Schwanhäusser, Björn, Busse, Dorothea, Li, Na, Dittmar, Gunnar, Schuchhardt, Johannes, Wolf, Jana, Chen, Wei, Selbach, Matthias
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Sprache:eng
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Zusammenfassung:[...]the estimated maximum translation rate constant in sea urchin embryos at 15 uC (140 proteins per mRNA per hour) is lower than our corrected prediction for mouse fibroblasts (1,000 proteins per mRNA per hour). Overall, copy number estimates of the eight proteins obtained by alternative approaches correlated well with our data derived from liquid chromatography and tandem mass spectrometry (LC-MS/MS) (Fig. 1b of this Corrigendum), even though the two measurements based on selected reaction monitoring lie above the diagonal.
ISSN:0028-0836
1476-4687
1476-4687
DOI:10.1038/nature11848