Prevalence of Chlamydophila pneumoniae antibodies in women with pre-eclampsia in Lagos, Nigeria

The precise aetiology of pre-eclampsia has remained unknown. It is still a major contributor to maternal and perinatal morbidity and mortality. To determine the relationship between pre-eclampsia and immunoglobulin G (IgG) antibodies to Chlamydophila pneumoniae. One hundred and eleven parturients in...

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Veröffentlicht in:West African journal of medicine 2012-10, Vol.31 (4), p.253-258
Hauptverfasser: Awoleke, J O, Ajayi, G O, Adegbola, O
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Sprache:eng
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Zusammenfassung:The precise aetiology of pre-eclampsia has remained unknown. It is still a major contributor to maternal and perinatal morbidity and mortality. To determine the relationship between pre-eclampsia and immunoglobulin G (IgG) antibodies to Chlamydophila pneumoniae. One hundred and eleven parturients in a tertiary hospital in Lagos, Nigeria comprising 49 women with pre-eclampsia and 62 women without pre-eclampsia were studied.Peripheral blood was obtained for Chlamydophila pneumoniae antibodies which were measured using a solid-phase enzyme-linked immunosorbent assay and maternal diastolic blood pressure, perinatal morbidity and mortality were also assessed. The cases (N = 49) and controls (N = 62) were evenly matched with respect to age and parity. The women with pre-eclampsia delivered at significantly lower gestational ages than those with normotensive gestations. 66.7% of all the subjects were seropositive for Chlamydophila pneumoniae antibodies. 38 out of the 49 cases (77.6%) were positive for the Chlamydophila pneumoniae antibodies compared with 36 out of the 62 controls (58.1%) [p0.05). Results from this study suggest a link between Chlamydophila pneumoniae IgG antibodies and pre-eclampsia. Further prospective studies with larger sizes are needed to verify this association and identify therapeutic options that will effectively prevent the onset or progression of pre-eclampsia.
ISSN:0189-160X