Appearance of neural stem cells around the damaged area following traumatic brain injury in aged rats

We have previously reported free radical production after traumatic brain injury (TBI), which induces neural stem cell (NSC) degeneration and death. However, the effects of aging on NSC proliferation around the damaged area following TBI have not been investigated. Therefore, in this study, we used...

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Veröffentlicht in:	Journal of Neural Transmission 2013-03, Vol.120 (3), p.361-374
Hauptverfasser:	Itoh, Tatsuki, Imano, Motohiro, Nishida, Shozo, Tsubaki, Masahiro, Nakayama, Takashi, Mizuguchi, Nobuyuki, Yamanaka, Shigeaki, Tabuchi, Masaki, Munakata, Hiroshi, Hashimoto, Shigeo, Ito, Akihiko, Satou, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aldehydes - analysis Animals Brain Injuries - metabolism Brain Injuries - pathology Cell culture Cell Differentiation - physiology Deoxyguanosine - analogs & derivatives Deoxyguanosine - analysis Deoxyguanosine - biosynthesis Disease Models, Animal DNA DNA, Single-Stranded - analysis Fluorescent Antibody Technique Free radicals Glia Immunohistochemistry Intermediate Filament Proteins - analysis Intermediate Filament Proteins - biosynthesis Lipid peroxidation Lipid Peroxidation - physiology Male Medicine Medicine & Public Health Nerve Tissue Proteins - analysis Nerve Tissue Proteins - biosynthesis Nestin Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurodegeneration Neurology Neurons Neurosciences neurospheres Peroxidation Psychiatry Rats Rats, Wistar Translational Neurosciences - Original Article Traumatic brain injury
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Zusammenfassung:	We have previously reported free radical production after traumatic brain injury (TBI), which induces neural stem cell (NSC) degeneration and death. However, the effects of aging on NSC proliferation around the damaged area following TBI have not been investigated. Therefore, in this study, we used 10-week (young group) and 24-month-old (aged group) rat TBI models to investigate the effects of aging on NSC proliferation around damaged tissue using immunohistochemical and ex vivo techniques. Young and aged rats received TBI. At 1, 3 and 7 days after TBI, immunohistochemical and lipid peroxidation studies were performed. Immunohistochemistry revealed that the number of nestin-positive cells around the damaged area after TBI in the aged group decreased significantly when compared with those in the young group ( P
ISSN:	0300-9564 1435-1463
DOI:	10.1007/s00702-012-0895-7