Cellular and molecular mechanisms of atherogenesis. CD40-CD40L immunoregulatory signal

Cellular and molecular mechanisms of atherogenesis. CD40-CD40L immunoregulatory signal

Contact-dependent interactions of CD40 receptor and its ligand CD40L are regarded as a stimulator of atheroma-associated cells. A new T lymphocyte-dependent pathway of activation of immune inflammation in the vascular wall is discussed, which is presumably maintained by self-regulation of antiinflam...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1999-10, Vol.128 (4), p.971-977
Hauptverfasser: Nagornev, V. A., Ketlinskii, S. A.
Format: Artikel
Sprache:eng
Schlagworte:
Atherogenesis
CD40 antigen
CD40L protein
Cell activation
Cytokines
Immunoregulation
Inflammation
Molecular modelling
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Zusammenfassung:Contact-dependent interactions of CD40 receptor and its ligand CD40L are regarded as a stimulator of atheroma-associated cells. A new T lymphocyte-dependent pathway of activation of immune inflammation in the vascular wall is discussed, which is presumably maintained by self-regulation of antiinflammatory cytokine production.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433181