The validity of biochemical markers in metabolic bone disease in preterm infants: a systematic review
To establish the validity of biochemical markers of metabolic bone disease (MBD) in preterm infants. Conclusion: There is insufficient evidence that any of the frequently used serum measurements are valid biochemical markers of MBD in preterm infants. Increased urinary calcium concentration may be...
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Veröffentlicht in: | Acta Paediatrica 2012-06, Vol.101 (6), p.562-568 |
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creator | Visser, Fenna Sprij, Arwen J Brus, Frank |
description | To establish the validity of biochemical markers of metabolic bone disease (MBD) in preterm infants.
Conclusion: There is insufficient evidence that any of the frequently used serum measurements are valid biochemical markers of MBD in preterm infants. Increased urinary calcium concentration may be a valid biochemical marker, but more research is necessary to confirm this. |
doi_str_mv | 10.1111/j.1651-2227.2012.02626.x |
format | Article |
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Conclusion: There is insufficient evidence that any of the frequently used serum measurements are valid biochemical markers of MBD in preterm infants. Increased urinary calcium concentration may be a valid biochemical marker, but more research is necessary to confirm this.</description><subject>Babies</subject><subject>Biochemical markers</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Bone diseases</subject><subject>Bone Diseases, Metabolic - blood</subject><subject>Bone Diseases, Metabolic - urine</subject><subject>Calcium (urinary)</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - blood</subject><subject>Infant, Premature, Diseases - urine</subject><subject>Infants</subject><subject>Medical sciences</subject><subject>Metabolic bone diseases</subject><subject>Neonatology</subject><subject>Premature birth</subject><subject>Premature infants</subject><subject>Reproducibility of Results</subject><subject>Reviews</subject><subject>Validity</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktvEzEURi0EoqHwF5AlhMRmgh9zPQ4Si1BoQFSAUClLy-Ncqw7zCPakTf59PSQEiQ144yv5fH7cY0IoZ1Oex8vVlCvghRCimgrGxZQJJdR0e49Mjgv3yYRpJgsQIE_Io5RWjAk5K9VDciKE5FJKNSF4eY30xjZhGYYd7T2tQ--usQ3ONrS18QfGRENHWxxs3TfB0brvkC5DQptwXFlHHDC2ufS2G9IramnapQFbO2Q64k3A28fkgbdNwieH-ZR8O393efa-uPi8-HA2vygcqFIV3pXgvah9qWoNsNTAlAXwinEEkF6jqwGsRy249bLmcuZtWSFKDihrJ0_Ji_2-69j_3GAaTBuSw6axHfabZHgGFQcu2b9RxnO7KqXLjD77C131m9jlhxgOZamrisFI6T3lYp9SRG_WMeQO7vJWZrRmVmaUY0Y5ZrRmflkz2xx9ejhgU7e4PAZ_a8rA8wNgUxbjo-1cSH84mAmd75u513vuNjS4--8LmPmX-VjlfLHPhyxwe8znb2BUJSsw3z8tzBs9u7pavP1ovso72mrBNw</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Visser, Fenna</creator><creator>Sprij, Arwen J</creator><creator>Brus, Frank</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201206</creationdate><title>The validity of biochemical markers in metabolic bone disease in preterm infants: a systematic review</title><author>Visser, Fenna ; Sprij, Arwen J ; Brus, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5646-fc45ff2bf46b855d8506a55f601e553f8ecb55afe821af3b139fa47ee315e3bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Babies</topic><topic>Biochemical markers</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Bone diseases</topic><topic>Bone Diseases, Metabolic - blood</topic><topic>Bone Diseases, Metabolic - urine</topic><topic>Calcium (urinary)</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - blood</topic><topic>Infant, Premature, Diseases - urine</topic><topic>Infants</topic><topic>Medical sciences</topic><topic>Metabolic bone diseases</topic><topic>Neonatology</topic><topic>Premature birth</topic><topic>Premature infants</topic><topic>Reproducibility of Results</topic><topic>Reviews</topic><topic>Validity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visser, Fenna</creatorcontrib><creatorcontrib>Sprij, Arwen J</creatorcontrib><creatorcontrib>Brus, Frank</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visser, Fenna</au><au>Sprij, Arwen J</au><au>Brus, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The validity of biochemical markers in metabolic bone disease in preterm infants: a systematic review</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2012-06</date><risdate>2012</risdate><volume>101</volume><issue>6</issue><spage>562</spage><epage>568</epage><pages>562-568</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>To establish the validity of biochemical markers of metabolic bone disease (MBD) in preterm infants.
Conclusion: There is insufficient evidence that any of the frequently used serum measurements are valid biochemical markers of MBD in preterm infants. Increased urinary calcium concentration may be a valid biochemical marker, but more research is necessary to confirm this.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22313336</pmid><doi>10.1111/j.1651-2227.2012.02626.x</doi><tpages>7</tpages></addata></record> |
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subjects | Babies Biochemical markers Biological and medical sciences Biomarkers - blood Biomarkers - urine Bone diseases Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - urine Calcium (urinary) General aspects Humans Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases - blood Infant, Premature, Diseases - urine Infants Medical sciences Metabolic bone diseases Neonatology Premature birth Premature infants Reproducibility of Results Reviews Validity |
title | The validity of biochemical markers in metabolic bone disease in preterm infants: a systematic review |
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