The validity of biochemical markers in metabolic bone disease in preterm infants: a systematic review

To establish the validity of biochemical markers of metabolic bone disease (MBD) in preterm infants. Conclusion: There is insufficient evidence that any of the frequently used serum measurements are valid biochemical markers of MBD in preterm infants. Increased urinary calcium concentration may be...

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Veröffentlicht in:	Acta Paediatrica 2012-06, Vol.101 (6), p.562-568
Hauptverfasser:	Visser, Fenna, Sprij, Arwen J, Brus, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Babies Biochemical markers Biological and medical sciences Biomarkers - blood Biomarkers - urine Bone diseases Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - urine Calcium (urinary) General aspects Humans Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases - blood Infant, Premature, Diseases - urine Infants Medical sciences Metabolic bone diseases Neonatology Premature birth Premature infants Reproducibility of Results Reviews Validity
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Beschreibung
Zusammenfassung:	To establish the validity of biochemical markers of metabolic bone disease (MBD) in preterm infants. Conclusion: There is insufficient evidence that any of the frequently used serum measurements are valid biochemical markers of MBD in preterm infants. Increased urinary calcium concentration may be a valid biochemical marker, but more research is necessary to confirm this.
ISSN:	0803-5253 1651-2227
DOI:	10.1111/j.1651-2227.2012.02626.x