Sensitive detection of hepatocellular injury in chronic hepatitis C patients with circulating hepatocyte-derived microRNA-122

Summary As chronic hepatitis C patients with progressive disease can present themselves with normal ALT levels, more sensitive biomarkers are needed. MicroRNAs are newly discovered small noncoding RNAs that are stable and detectable in the circulation. We aimed to investigate the association between...

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Veröffentlicht in:	Journal of viral hepatitis 2013-03, Vol.20 (3), p.158-166
Hauptverfasser:	van der Meer, A. J., Farid, W. R. R., Sonneveld, M. J., de Ruiter, P. E., Boonstra, A., van Vuuren, A. J., Verheij, J., Hansen, B. E., de Knegt, R. J., van der Laan, L. J. W., Janssen, H. L. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alanine Transaminase - blood ALT Biomarkers - blood Blood chronic hepatitis C Female Hepatitis C virus Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - pathology Humans Liver - pathology liver injury Male microRNA MicroRNAs - blood Middle Aged miRNA-122 Sensitivity and Specificity
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Zusammenfassung:	Summary As chronic hepatitis C patients with progressive disease can present themselves with normal ALT levels, more sensitive biomarkers are needed. MicroRNAs are newly discovered small noncoding RNAs that are stable and detectable in the circulation. We aimed to investigate the association between hepatocyte‐derived microRNAs in serum and liver injury in patients with chronic hepatitis C. The hepatocyte‐derived miR‐122 and miR‐192 were analysed in sera of 102 chronic HCV‐infected patients and 24 healthy controls. Serum levels of miR‐122 and miR‐192 correlated strongly with ALT (R = 0.67 and R = 0.65, respectively, P
ISSN:	1352-0504 1365-2893
DOI:	10.1111/jvh.12001