Two acute myeloblastic leukemia cases concomitant with hemophagocytic lymphohistiocytosis and review of the literature

Two acute myeloblastic leukemia cases concomitant with hemophagocytic lymphohistiocytosis and review of the literature

We present two patients with acute myeloblastic leukemia (FAB AML-M7 and AML-M2) complicated by hemophagocytic lymphohistiocytosis (HLH) and relevant literature review. To our knowledge, our first case is the first and youngest patient having AML-M7 associated with HLH reported in the literature. Ou...

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Veröffentlicht in:Annals of clinical and laboratory science 2013, Vol.43 (1), p.85-90
Hauptverfasser: Akyay, Arzu, Celkan, Tiraje, Iskender, Gülşen, Tükün, Ajlan, Ogan, Cihat, Olcay, Lale
Format: Artikel
Sprache:eng
Schlagworte:
Child
Fatal Outcome
Female
Histiocytes - pathology
Humans
Infant
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - pathology
Lymphohistiocytosis, Hemophagocytic - complications
Lymphohistiocytosis, Hemophagocytic - pathology
Megakaryocytes - pathology
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Zusammenfassung:We present two patients with acute myeloblastic leukemia (FAB AML-M7 and AML-M2) complicated by hemophagocytic lymphohistiocytosis (HLH) and relevant literature review. To our knowledge, our first case is the first and youngest patient having AML-M7 associated with HLH reported in the literature. Our cases and cases in the literature highlight the high mortality rate of leukemia associated with HLH and the need for further investigation for the most appropriate therapy.
ISSN:1550-8080