Synthesis of LipidGreen2 and its application in lipid and fatty liver imaging

We have developed LipidGreen2, a second generation small molecule probe for lipid imaging. LipidGreen2 has a better fluorescence signal compared with the previous LipidGreen, and selectively stains neutral lipids in cells and fat deposits in live zebrafish. We also demonstrate the application of Lip...

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Veröffentlicht in:	Molecular bioSystems 2013-04, Vol.9 (4), p.630-633
Hauptverfasser:	Chun, Hang-Suk, Jeon, Jong Hyun, Pagire, Haushabhau S, Lee, Jae Hong, Chung, Hee-Chung, Park, Myoung Joo, So, Ju-Hoon, Ryu, Jae-Ho, Kim, Cheol-Hee, Ahn, Jin Hee, Bae, Myung Ae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Fatty Liver - diagnosis Fluorescent Dyes - chemistry Humans Lipids - chemical synthesis Lipids - chemistry Mice Molecular Imaging - methods Molecular Probes - chemistry Zebrafish
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Beschreibung
Zusammenfassung:	We have developed LipidGreen2, a second generation small molecule probe for lipid imaging. LipidGreen2 has a better fluorescence signal compared with the previous LipidGreen, and selectively stains neutral lipids in cells and fat deposits in live zebrafish. We also demonstrate the application of LipidGreen2 for detecting fatty liver.
ISSN:	1742-206X 1742-2051
DOI:	10.1039/c3mb70022d