IsoDGR-Tagged Albumin: A New αvβ3 Selective Carrier for Nanodrug Delivery to Tumors

A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR‐tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature‐selective nanomedicines,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2013-03, Vol.9 (5), p.673-678
Hauptverfasser:	Curnis, Flavio, Sacchi, Angelina, Longhi, Renato, Colombo, Barbara, Gasparri, Anna, Corti, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	cyclic peptides drug delivery Gold - chemistry gold nanoparticles human serum albumin Humans Integrin alphaVbeta3 - administration & dosage Integrin alphaVbeta3 - chemistry Metal Nanoparticles - chemistry Neoplasms - metabolism Tumor Necrosis Factor-alpha - chemistry tumor necrosis factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR‐tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature‐selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.201202310