Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation
Highlights ► Single intrathecal BDNF injection caused transient bladder hyperactivity and pain. ► Chronic intrathecal administration of BDNF induced cutaneous hypersensitivity. ► Chronic intrathecal administration of BDNF did not affect bladder reflex activity. ► Intrathecal BDNF blockade reduced pa...
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| Veröffentlicht in: | Neuroscience 2013-03, Vol.234, p.88-102 |
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| creator | Frias, B Allen, S Dawbarn, D Charrua, A Cruz, F Cruz, C.D |
| description | Highlights ► Single intrathecal BDNF injection caused transient bladder hyperactivity and pain. ► Chronic intrathecal administration of BDNF induced cutaneous hypersensitivity. ► Chronic intrathecal administration of BDNF did not affect bladder reflex activity. ► Intrathecal BDNF blockade reduced pain and bladder hyperactivity during cystitis. |
| doi_str_mv | 10.1016/j.neuroscience.2012.12.044 |
| format | Article |
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Urinary tract diseases ; Neurology ; Pain, Referred - physiopathology ; Protein Kinase Inhibitors - pharmacology ; Rats ; Receptor, trkB - antagonists & inhibitors ; Spinal Cord - drug effects ; Spinal Cord - physiopathology ; Urinary Bladder - drug effects ; Urinary Bladder - physiology ; Urinary Bladder - physiopathology ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland ; visceral pain</subject><ispartof>Neuroscience, 2013-03, Vol.234, p.88-102</ispartof><rights>IBRO</rights><rights>2013 IBRO</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 IBRO. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-9df726757d7a649cbb167f1664692e5c7d13f50102b0f3f6615d43294b74209e3</citedby><cites>FETCH-LOGICAL-c465t-9df726757d7a649cbb167f1664692e5c7d13f50102b0f3f6615d43294b74209e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452212012390$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27162004$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23313710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frias, B</creatorcontrib><creatorcontrib>Allen, S</creatorcontrib><creatorcontrib>Dawbarn, D</creatorcontrib><creatorcontrib>Charrua, A</creatorcontrib><creatorcontrib>Cruz, F</creatorcontrib><creatorcontrib>Cruz, C.D</creatorcontrib><title>Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights ► Single intrathecal BDNF injection caused transient bladder hyperactivity and pain. ► Chronic intrathecal administration of BDNF induced cutaneous hypersensitivity. ► Chronic intrathecal administration of BDNF did not affect bladder reflex activity. ► Intrathecal BDNF blockade reduced pain and bladder hyperactivity during cystitis.</description><subject>Animals</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the urinary system</subject><subject>BDNF</subject><subject>Biological and medical sciences</subject><subject>bladder</subject><subject>bladder hyperactivity</subject><subject>Brain-Derived Neurotrophic Factor - administration & dosage</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Brain-Derived Neurotrophic Factor - pharmacology</subject><subject>Brain-Derived Neurotrophic Factor - physiology</subject><subject>Carbazoles - pharmacology</subject><subject>Cyclophosphamide</subject><subject>cystitis</subject><subject>Cystitis - chemically induced</subject><subject>Cystitis - metabolism</subject><subject>Cystitis - physiopathology</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Indole Alkaloids - pharmacology</subject><subject>Infectious diseases</subject><subject>inflammation</subject><subject>Injections, Spinal</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Neurology</subject><subject>Pain, Referred - physiopathology</subject><subject>Protein Kinase Inhibitors - pharmacology</subject><subject>Rats</subject><subject>Receptor, trkB - antagonists & inhibitors</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - physiopathology</subject><subject>Urinary Bladder - drug effects</subject><subject>Urinary Bladder - physiology</subject><subject>Urinary Bladder - physiopathology</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><subject>visceral pain</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsuqFDEQDaJ4x9FfkCAILm6PeXViuxD0-oQLLtR1SCfVTsZMuk3SA_M1_qppZ66KK0NBbc4jVacQekTJhhIqn-42EeY0ZushWtgwQtmmFhHiFlrRZ4o3qhXiNloRTmQjWsYu0L2cd6S-VvC76IJxTrmiZIV-vErGx8ZB8gdw-JdwSeO09RYPxpYxXeLafPyKTcFlCzhPPpqA7ZgcDnCAcIknk4q3fjIFMvYR98G4qoi3xwnSwj74csQmOpxggJSq0VRdsZvTImy3aYzV74bm4xDMfm-KH-N9dGcwIcODc1-jL2_ffL5631x_fPfh6uV1Y4VsS9O5QTGpWuWUkaKzfU-lGqiUQnYMWqsc5UNLKGE9GfggJW2d4KwTvRKMdMDX6MlJd0rj9xly0XufLYRgIoxz1pRTURfG6-bW6PkJamsGuU6kp-T3Jh01JXoJSO_03wHpJSBdqwZUyQ_PPnO_B_ebepNIBTw-A0y2JgzJROvzH5yikhGyCL0-4aBu5eAh6bOd8wls0W70__efF__I2OBrGCZ8gyPk3TinmnadX-dK0J-Wk1ouii4ivCP8Jyp7zPE</recordid><startdate>20130327</startdate><enddate>20130327</enddate><creator>Frias, B</creator><creator>Allen, S</creator><creator>Dawbarn, D</creator><creator>Charrua, A</creator><creator>Cruz, F</creator><creator>Cruz, C.D</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130327</creationdate><title>Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation</title><author>Frias, B ; Allen, S ; Dawbarn, D ; Charrua, A ; Cruz, F ; Cruz, C.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-9df726757d7a649cbb167f1664692e5c7d13f50102b0f3f6615d43294b74209e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the urinary system</topic><topic>BDNF</topic><topic>Biological and medical sciences</topic><topic>bladder</topic><topic>bladder hyperactivity</topic><topic>Brain-Derived Neurotrophic Factor - administration & dosage</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Brain-Derived Neurotrophic Factor - pharmacology</topic><topic>Brain-Derived Neurotrophic Factor - physiology</topic><topic>Carbazoles - pharmacology</topic><topic>Cyclophosphamide</topic><topic>cystitis</topic><topic>Cystitis - chemically induced</topic><topic>Cystitis - metabolism</topic><topic>Cystitis - physiopathology</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Indole Alkaloids - pharmacology</topic><topic>Infectious diseases</topic><topic>inflammation</topic><topic>Injections, Spinal</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Neurology</topic><topic>Pain, Referred - physiopathology</topic><topic>Protein Kinase Inhibitors - pharmacology</topic><topic>Rats</topic><topic>Receptor, trkB - antagonists & inhibitors</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - physiopathology</topic><topic>Urinary Bladder - drug effects</topic><topic>Urinary Bladder - physiology</topic><topic>Urinary Bladder - physiopathology</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><topic>visceral pain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frias, B</creatorcontrib><creatorcontrib>Allen, S</creatorcontrib><creatorcontrib>Dawbarn, D</creatorcontrib><creatorcontrib>Charrua, A</creatorcontrib><creatorcontrib>Cruz, F</creatorcontrib><creatorcontrib>Cruz, C.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frias, B</au><au>Allen, S</au><au>Dawbarn, D</au><au>Charrua, A</au><au>Cruz, F</au><au>Cruz, C.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2013-03-27</date><risdate>2013</risdate><volume>234</volume><spage>88</spage><epage>102</epage><pages>88-102</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Highlights ► Single intrathecal BDNF injection caused transient bladder hyperactivity and pain. ► Chronic intrathecal administration of BDNF induced cutaneous hypersensitivity. ► Chronic intrathecal administration of BDNF did not affect bladder reflex activity. ► Intrathecal BDNF blockade reduced pain and bladder hyperactivity during cystitis.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>23313710</pmid><doi>10.1016/j.neuroscience.2012.12.044</doi><tpages>15</tpages></addata></record> |
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| subjects | Animals Bacterial diseases Bacterial diseases of the urinary system BDNF Biological and medical sciences bladder bladder hyperactivity Brain-Derived Neurotrophic Factor - administration & dosage Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - pharmacology Brain-Derived Neurotrophic Factor - physiology Carbazoles - pharmacology Cyclophosphamide cystitis Cystitis - chemically induced Cystitis - metabolism Cystitis - physiopathology Extracellular Signal-Regulated MAP Kinases - metabolism Female Human bacterial diseases Indole Alkaloids - pharmacology Infectious diseases inflammation Injections, Spinal Medical sciences Nephrology. Urinary tract diseases Neurology Pain, Referred - physiopathology Protein Kinase Inhibitors - pharmacology Rats Receptor, trkB - antagonists & inhibitors Spinal Cord - drug effects Spinal Cord - physiopathology Urinary Bladder - drug effects Urinary Bladder - physiology Urinary Bladder - physiopathology Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland visceral pain |
| title | Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation |
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