Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation

Highlights ► Single intrathecal BDNF injection caused transient bladder hyperactivity and pain. ► Chronic intrathecal administration of BDNF induced cutaneous hypersensitivity. ► Chronic intrathecal administration of BDNF did not affect bladder reflex activity. ► Intrathecal BDNF blockade reduced pa...

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Veröffentlicht in:	Neuroscience 2013-03, Vol.234, p.88-102
Hauptverfasser:	Frias, B, Allen, S, Dawbarn, D, Charrua, A, Cruz, F, Cruz, C.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial diseases Bacterial diseases of the urinary system BDNF Biological and medical sciences bladder bladder hyperactivity Brain-Derived Neurotrophic Factor - administration & dosage Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - pharmacology Brain-Derived Neurotrophic Factor - physiology Carbazoles - pharmacology Cyclophosphamide cystitis Cystitis - chemically induced Cystitis - metabolism Cystitis - physiopathology Extracellular Signal-Regulated MAP Kinases - metabolism Female Human bacterial diseases Indole Alkaloids - pharmacology Infectious diseases inflammation Injections, Spinal Medical sciences Nephrology. Urinary tract diseases Neurology Pain, Referred - physiopathology Protein Kinase Inhibitors - pharmacology Rats Receptor, trkB - antagonists & inhibitors Spinal Cord - drug effects Spinal Cord - physiopathology Urinary Bladder - drug effects Urinary Bladder - physiology Urinary Bladder - physiopathology Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland visceral pain
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Zusammenfassung:	Highlights ► Single intrathecal BDNF injection caused transient bladder hyperactivity and pain. ► Chronic intrathecal administration of BDNF induced cutaneous hypersensitivity. ► Chronic intrathecal administration of BDNF did not affect bladder reflex activity. ► Intrathecal BDNF blockade reduced pain and bladder hyperactivity during cystitis.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.12.044