Tuning the threshold of natural killer cell responses

Highlights ► Temporal orchestration of transcription factors for NK cell development. ► NK cell maturation depends on accessory cells. ► NK cell responsiveness is tuned by the environment. ► Intensity of inflammation dictates the antiviral and immunoregulatory outcome of NK cell activation.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in immunology 2013-02, Vol.25 (1), p.53-58
Hauptverfasser:	Narni-Mancinelli, Emilie, Ugolini, Sophie, Vivier, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cell Differentiation Cellular Microenvironment - immunology Cytokines - immunology Cytotoxicity, Immunologic Humans Immunity, Innate Immunomodulation Killer Cells, Natural - immunology Lymphocyte Activation Signal Transduction Virus Diseases - immunology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights ► Temporal orchestration of transcription factors for NK cell development. ► NK cell maturation depends on accessory cells. ► NK cell responsiveness is tuned by the environment. ► Intensity of inflammation dictates the antiviral and immunoregulatory outcome of NK cell activation.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2012.11.005