Human leukocyte antigen-associated drug hypersensitivity

Highlights ► Associations between the human leukocyte antigen (HLA) and adverse drug reactions are discussed. ► We discuss evidence that interaction of HLA-B*57:01 and abacavir leads to T cell responses. ► Mechanisms of interactions between carbamazepine and HLA-B*15:02 and HLA-A*31:01 are discussed...

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Veröffentlicht in:	Current opinion in immunology 2013-02, Vol.25 (1), p.81-89
Hauptverfasser:	Illing, Patricia T, Vivian, Julian P, Purcell, Anthony W, Rossjohn, Jamie, McCluskey, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Antigen Presentation - drug effects Autoantigens - metabolism Carbamazepine - adverse effects Carbamazepine - therapeutic use Dideoxynucleosides - adverse effects Dideoxynucleosides - therapeutic use Drug Hypersensitivity - genetics Drug Hypersensitivity - immunology HIV Infections - complications HIV Infections - drug therapy HLA Antigens - immunology HLA Antigens - metabolism Humans Peptide Fragments - metabolism Protein Binding - drug effects Seizures - drug therapy Skin - drug effects Skin - pathology
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Zusammenfassung:	Highlights ► Associations between the human leukocyte antigen (HLA) and adverse drug reactions are discussed. ► We discuss evidence that interaction of HLA-B57:01 and abacavir leads to T cell responses. ► Mechanisms of interactions between carbamazepine and HLA-B15:02 and HLA-A*31:01 are discussed. ► We discuss evidence of other small molecules influencing peptide presentation by HLA.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2012.10.002