Ceramicines from Chisocheton ceramicus as lipid-droplets accumulation inhibitors

In our search for lipid-droplets accumulation (LDA) inhibitors, some ceramicines, a series of limonoids isolated from the barks of Chisocheton ceramicus, were discovered to be active as anti-LDA. Preliminary structure–activity relationships (SAR) of ceramicines as LDA inhibitors based on ceramicines...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-03, Vol.23 (6), p.1786-1788
Hauptverfasser:	Wong, Chin Piow, Deguchi, Jun, Nugroho, Alfarius Eko, Kaneda, Toshio, Hadi, A. Hamid. A., Morita, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Survival - drug effects Ceramicines Chisocheton Limonins - chemistry Limonins - metabolism Limonins - toxicity Limonoids Lipid Metabolism - drug effects Lipid-droplets accumulation Meliaceae - chemistry Mice Plant Bark - chemistry Protein Binding Structure-Activity Relationship structure-activity relationships
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In our search for lipid-droplets accumulation (LDA) inhibitors, some ceramicines, a series of limonoids isolated from the barks of Chisocheton ceramicus, were discovered to be active as anti-LDA. Preliminary structure–activity relationships (SAR) of ceramicines as LDA inhibitors based on ceramicines A–L (1–12) and ceramicine B derivatives were described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2013.01.037