High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

A highly selective and sensitive near-infrared (NIR) fluorescence probe (Cy-NO2) for imaging nitroreductase was developed and was successfully applied to investigating the relationship between epithelial-mesenchymal transitions (EMTs) in tumour progression and intracellular hypoxic level.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (25), p.2554-2556
Hauptverfasser:	Xu, Kehua, Wang, Feng, Pan, Xiaohong, Liu, Renpu, Ma, Jing, Kong, Fanpeng, Tang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzothiazoles - chemistry Carbocyanines - chemistry Cell Hypoxia Cell Survival - drug effects Fluorescent Dyes - chemistry Fluorescent Dyes - toxicity Hep G2 Cells Humans Microscopy, Fluorescence Microsomes, Liver - metabolism Neoplasms - enzymology Neoplasms - pathology Nitrogen Dioxide - chemistry Nitroreductases - chemistry Nitroreductases - metabolism Spectroscopy, Near-Infrared
Online-Zugang:	Volltext
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