High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

A highly selective and sensitive near-infrared (NIR) fluorescence probe (Cy-NO2) for imaging nitroreductase was developed and was successfully applied to investigating the relationship between epithelial-mesenchymal transitions (EMTs) in tumour progression and intracellular hypoxic level.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (25), p.2554-2556
Hauptverfasser: Xu, Kehua, Wang, Feng, Pan, Xiaohong, Liu, Renpu, Ma, Jing, Kong, Fanpeng, Tang, Bo
Format: Artikel
Sprache:eng
Schlagworte:
Benzothiazoles - chemistry
Carbocyanines - chemistry
Cell Hypoxia
Cell Survival - drug effects
Fluorescent Dyes - chemistry
Fluorescent Dyes - toxicity
Hep G2 Cells
Humans
Microscopy, Fluorescence
Microsomes, Liver - metabolism
Neoplasms - enzymology
Neoplasms - pathology
Nitrogen Dioxide - chemistry
Nitroreductases - chemistry
Nitroreductases - metabolism
Spectroscopy, Near-Infrared
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Beschreibung
Zusammenfassung:A highly selective and sensitive near-infrared (NIR) fluorescence probe (Cy-NO2) for imaging nitroreductase was developed and was successfully applied to investigating the relationship between epithelial-mesenchymal transitions (EMTs) in tumour progression and intracellular hypoxic level.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc38980d