The effect of sildenafil on retinopathy of prematurity in very preterm infants

The effect of sildenafil on retinopathy of prematurity in very preterm infants

Objective: Sildenafil is occasionally used as rescue treatment for preterm infants with severe bronchopulmonary dysplasia and pulmonary arterial hypertension. In adults, sildenafil treatment has been associated with several ophthalmological adverse effects, including nonarteritic ischaemic optic neu...

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Veröffentlicht in:Journal of perinatology 2013-03, Vol.33 (3), p.218-221
Hauptverfasser: Fang, A Y W, Guy, K J, König, K
Format: Artikel
Sprache:eng
Schlagworte:
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Birth weight
Bronchopulmonary Dysplasia - drug therapy
Case-Control Studies
Confidence intervals
Disease Progression
Drug therapy
Dysplasia
Eye examinations
Gestation
Gestational age
Health aspects
Humans
Hypertension
Infant, Newborn
Infant, Premature
Infants
Infants (Premature)
Ischemia
Lasers
Lung diseases
Medicine
Medicine & Public Health
Neonates
Newborn babies
Optic neuropathy
original-article
Pediatric Surgery
Pediatrics
Phosphodiesterase 5 Inhibitors - adverse effects
Phosphodiesterase 5 Inhibitors - therapeutic use
Piperazines - adverse effects
Piperazines - therapeutic use
Premature babies
Pulmonary hypertension
Purines - adverse effects
Purines - therapeutic use
Retinopathy
Retinopathy of Prematurity - chemically induced
Retrolental fibroplasia
Risk factors
Sildenafil
Sildenafil Citrate
Sulfones - adverse effects
Sulfones - therapeutic use
Ultrasonic imaging
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Zusammenfassung:Objective: Sildenafil is occasionally used as rescue treatment for preterm infants with severe bronchopulmonary dysplasia and pulmonary arterial hypertension. In adults, sildenafil treatment has been associated with several ophthalmological adverse effects, including nonarteritic ischaemic optic neuropathy. We reviewed the effect of sildenafil on retinopathy of prematurity (ROP) in very preterm infants. Study Design: Retrospective case–control study. Infants born
ISSN:0743-8346
1476-5543
DOI:10.1038/jp.2012.84